Matrix metalloproteinase 7 (MMP-7) and tissue inhibitor of metalloproteinases-2 (TIMP-2) downregulation complements PALG1 oncogene overexpression in pleomorphic adenoma pathogenesis

Pleomorphic adenoma (PA) is the most common neoplasm of salivary glands and consists epithelial mesenchymal components. Although a benign lesion, it harbors potential for recurrence malignant transformation. Also, due to its histological diversity unpredictive behavior PA can represent both diagnostic therapeutic challenge. Matrix metalloproteinases (MMPs) are well known modifiers extracellular matrix (ECM) component in conjunction with their endogenous tissue inhibitors (TIMPs) may influence tumor biology. PLAG1 oncogene also has an important role PA; however, neither exact mechanisms nor interactions other genes completely elucidated. The aims this study were assess expression PLAG1, MMP-2, MMP-7, MMP-9, TIMP-1 TIMP-2 PAs, find possible association gene levels clinical/epidemiological parameters patients. Relative mRNA assessed using Quantitative real-time PCR analyses 15 PAs parotid gland 5 normal (NSGs). A statistically significant overexpression was observed compared NSG samples (P=0.010); had 5.48 times higher than NSG. Out three analyzed MMP genes, significantly lower MMP-7 found patients (P=0.026). TIMP2 downregulated samples, NSGs (P=0.040). decreased 2.95 2.85 respectively, samples. No between parameters. Our results suggest that concomitant MMP7 downregulation contribute development.